Following is my implementation for Dependency Injection in MvcApplication class
public class MvcApplication : System.Web.HttpApplication { protected void Application_Start() { RegisterDependencies(); //pass service into other class that need this service var c = new OtherClassNeedService(_IYourService); } private AutofacDependencyResolver IoCcontainer { get; set; } private IYourService _IYourService { get { if (IoCcontainer == null) return null; return IoCcontainer.ApplicationContainer.Resolve(); } } public void RegisterDependencies() { var builder = new ContainerBuilder(); builder.RegisterControllers(typeof(MvcApplication).Assembly); builder.RegisterType () .As (); //.InstancePerHttpRequest(); if added InstancePerHttpRequest, will get error: No scope with a Tag matching 'httpRequest' is visible from the scope in which the instance was requested. IContainer container = builder.Build(); var aResolver = new AutofacDependencyResolver(container); DependencyResolver.SetResolver(aResolver); IoCcontainer = aResolver; } protected void Application_End(object sender, EventArgs e) { IoCcontainer.ApplicationContainer.Dispose(); } }